Which HIV drug class includes Efavirenz and Doravirine?

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Multiple Choice

Which HIV drug class includes Efavirenz and Doravirine?

Explanation:
Efavirenz and doravirine are in the non-nucleoside reverse transcriptase inhibitors class. NNRTIs bind to a pocket on reverse transcriptase away from the active site, causing a conformational change that blocks the enzyme’s ability to convert viral RNA into DNA. They don’t require activation by phosphorylation, unlike the nucleoside/nucleotide reverse transcriptase inhibitors, which are incorporated as false building blocks and terminate DNA synthesis. This mechanism is distinct from protease inhibitors, which prevent viral maturation, and from integrase inhibitors, which block integration of viral DNA into the host genome.

Efavirenz and doravirine are in the non-nucleoside reverse transcriptase inhibitors class. NNRTIs bind to a pocket on reverse transcriptase away from the active site, causing a conformational change that blocks the enzyme’s ability to convert viral RNA into DNA. They don’t require activation by phosphorylation, unlike the nucleoside/nucleotide reverse transcriptase inhibitors, which are incorporated as false building blocks and terminate DNA synthesis. This mechanism is distinct from protease inhibitors, which prevent viral maturation, and from integrase inhibitors, which block integration of viral DNA into the host genome.

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