In cholera, what is the mainstay initial therapy?

• A. Doxycycline
• B. ORS
• C. Azithromycin
• D. Ciprofloxacin

Answer: (B)

Cholera’s danger is rapid dehydration from profuse watery stools, so the first priority is to restore fluid and electrolyte balance as quickly as possible. Oral rehydration solution provides the right mix of water, electrolytes, and glucose to maximize absorption in the gut and replace losses efficiently, making it safe and effective even in low-resource settings. This rehydration approach directly addresses the life-threatening part of the illness, which is why it is the mainstay of initial therapy. Antibiotics can help shorten the course and reduce stool output, but they do not replace the need for prompt rehydration and are considered adjuncts in many cases. If a patient cannot take fluids by mouth, or if dehydration is severe, intravenous fluids are used, and zinc supplementation helps children.